Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH1 | Q92800 | 5/20 | 0.42 |
| ▸ | EZH2 | Q15910 | 8/20 | 0.42 |
| ▸ | PDE9A | O76083 | 7/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.37 |
| ▸ | EED | O75530 | 3/20 | 0.37 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.37 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.37 |
| ▸ | RBBP7 | Q16576 | 3/20 | 0.37 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.37 |
| ▸ | PRMT3 | O60678 | 2/20 | 0.37 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800382 | 0.94 | EZH1 (0.44) | EZH1EZH2PDE9APDE1C | |
| SCHEMBL18800353 | 0.91 | EZH1 (0.42) | EZH1EZH2PDE9APDE1C | |
| SCHEMBL18800384 | 0.86 | PDE9A (0.45) | EZH1EZH2PDE9APDE1C | |
| SCHEMBL12684237 | 0.86 | EZH1 (0.53) | EZH1EZH2EEDRBBP4SUZ12 | |
| SCHEMBL18800350 | 0.85 | EZH2 (0.54) | EZH1EZH2PDE9AEEDRBBP4 | |
| SCHEMBL18800352 | 0.85 | EZH1 (0.43) | EZH1EZH2PDE9APDE1C | |
| SCHEMBL18800424 | 0.82 | EZH1 (0.41) | EZH1EZH2PDE9APDE1C | |
| SCHEMBL18800360 | 0.81 | EZH2 (0.43) | EZH1EZH2PDE9AEEDRBBP4 | |
| SCHEMBL12684434 | 0.80 | EZH2 (0.55) | EZH1EZH2EEDRBBP4SUZ12 | |
| SCHEMBL12684422 | 0.79 | EZH2 (0.56) | EZH1EZH2EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |