Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 12/20 | 0.41 |
| ▸ | PDE9A | O76083 | 8/20 | 0.39 |
| ▸ | EED | O75530 | 1/20 | 0.36 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.36 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.36 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800373 | 0.88 | EZH2 (0.37) | EZH2PDE9AEEDRBBP4SUZ12 | |
| SCHEMBL12684301 | 0.86 | EZH2 (0.55) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL21418328 | 0.85 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL19958912 | 0.81 | EZH2 (0.46) | EZH2PDE9AEEDRBBP4SUZ12 | |
| SCHEMBL19391595 | 0.80 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684232 | 0.79 | EZH2 (0.63) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL22517709 | 0.77 | EZH2 (0.47) | EZH2PDE9AEEDRBBP4SUZ12 | |
| SCHEMBL12683938 | 0.76 | EZH2 (0.52) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12498796 | 0.75 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL19430090 | 0.75 | CARM1 (0.38) | EZH2PDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9637472-B2 | Substituted 6,5-fused bicyclic heteroaryl compounds | Epizyme, Inc. (US) | 2017-05-02 | — | — | US | disclosed |