Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.51 |
| ▸ | EED | O75530 | 1/20 | 0.44 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.44 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.44 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12683912 | 0.86 | EZH2 (0.68) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL19958912 | 0.84 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL21418328 | 0.84 | EZH2 (0.46) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL22517696 | 0.83 | EZH2 (0.54) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12684039 | 0.82 | EZH2 (0.70) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL21418321 | 0.80 | EZH2 (0.53) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL18800391 | 0.80 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL18800373 | 0.79 | EZH2 (0.37) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL22517709 | 0.79 | EZH2 (0.47) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL12498796 | 0.79 | EZH2 (0.62) | EZH2EEDRBBP4SUZ12RBBP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3323820-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |
| EP-2681216-B1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |