Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.63 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | FAAH | O00519 | 4/20 | 0.55 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.51 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL791665 | 1.00 | VEGFA (0.63) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL22587046 | 0.90 | VEGFA (0.53) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL13479179 | 0.86 | HDAC8 (0.64) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL12642706 | 0.85 | HDAC8 (0.67) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL1241170 | 0.85 | HDAC8 (0.67) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL3565573 | 0.85 | HDAC8 (0.63) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL3569375 | 0.85 | HDAC8 (0.63) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL18700880 | 0.85 | FAAH (0.53) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL18700879 | 0.85 | FAAH (0.53) | VEGFAEGLN1HDAC8HDAC6HDAC1 | |
| SCHEMBL1241175 | 0.85 | HDAC8 (0.67) | VEGFAEGLN1HDAC8HDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585064-B1 | C5AR ANTAGONISTS | CHEMOCENTRYX INC (US) | 2017-05-03 | — | — | EP | disclosed |