Bromide

Bromide

SCHEMBL188022

CCCCOC(=O)C(C(=O)OCc1ccc2c(c1)OCO2)c1[nH]cc[n+]1C.[Br-]

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.47
TAS1R3 Q7RTX0 2/20 0.39
TAS1R1 Q7RTX1 2/20 0.39
NAAA Q02083 1/20 0.39
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
TSHR P16473 1/20 0.38
RAB9A P51151 3/20 0.38
NPC1 O15118 2/20 0.38
EDNRA P25101 1/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
HPGD P15428 2/20 0.38
LMNA P02545 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
FAAH O00519 1/20 0.38
MGLL Q99685 1/20 0.38
ALDH1A1 P00352 1/20 0.37
HTT P42858 1/20 0.37
KDM4E B2RXH2 1/20 0.37
MAPT P10636 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL187311 0.87 CYP3A4 (0.51) CYP3A4TAS1R3TAS1R1NAAARAB9A
SCHEMBL186839 0.85 CYP3A4 (0.39) CYP3A4TAS1R3TAS1R1NAAAMEN1
Bromide SCHEMBL785308 0.78 CYP3A4 (0.52) CYP3A4MEN1KMT2ATSHRRAB9A
SCHEMBL786373 0.77 CYP3A4 (0.53) CYP3A4MEN1KMT2ATSHRRAB9A
Bromide SCHEMBL786346 0.76 CYP3A4 (0.47) CYP3A4MEN1KMT2ATSHRRAB9A
SCHEMBL786172 0.75 CYP3A4 (0.48) CYP3A4MEN1KMT2ATSHRRAB9A
SCHEMBL785950 0.73 CYP3A4 (0.47) CYP3A4MEN1KMT2ATSHRRAB9A
SCHEMBL786171 0.73 CYP3A4 (0.48) CYP3A4NAAAMEN1KMT2ATSHR
Bromide SCHEMBL786196 0.73 CYP3A4 (0.46) CYP3A4TAS1R3TAS1R1MEN1KMT2A
SCHEMBL785951 0.72 CYP3A4 (0.47) CYP3A4TAS1R3TAS1R1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2401258-A1 IONIC LIQUID SOLVENTS Dublin City University (IE) 2012-01-04 EP claimed
WO-2010097412-A1 IONIC LIQUID SOLVENTS DUBLIN CITY UNIVERSITY (IE) 2010-09-02 WO claimed