Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 16/20 | 0.72 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.56 |
| ▸ | NMT1 | P30419 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18803521 | 0.89 | MKNK1 (0.69) | MKNK1MKNK2NMT1DYRK1B | |
| SCHEMBL18803567 | 0.88 | MKNK1 (0.73) | MKNK1MKNK2NMT1 | |
| SCHEMBL18803511 | 0.78 | MKNK1 (1.00) | MKNK1MKNK2NMT1DYRK1B | |
| SCHEMBL18803541 | 0.78 | MKNK1 (0.71) | MKNK1MKNK2DYRK1B | |
| SCHEMBL4906521 | 0.75 | ABL1 (0.50) | MKNK1MKNK2DYRK1B | |
| SCHEMBL7809553 | 0.73 | CSNK2A1 (0.71) | — | |
| SCHEMBL4904668 | 0.72 | DKK1 (0.43) | MKNK1MKNK2DYRK1B | |
| SCHEMBL18803509 | 0.71 | MKNK1 (1.00) | MKNK1MKNK2NMT1 | |
| SCHEMBL18812357 | 0.69 | MKNK1 (1.00) | MKNK1MKNK2NMT1 | |
| SCHEMBL13503011 | 0.69 | CSNK2A1 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851082-B2 | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2020-12-01 | — | — | US | disclosed |
| US-20170121326-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2017-05-04 | — | — | US | disclosed |
| US-20170121326-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2017-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851082-B2 | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) | MAP4K2, MAP3K20, MKNK2 | MKNK1 5/4885MKNK2 3/4885NMT1 1241/4885 |
| US-20170121326-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | MAP4K2, MAP3K20, MKNK2 | MKNK1 5/4885MKNK2 3/4885NMT1 1241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.