DKK1 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3643372	0.78	4/20
SCHEMBL3644149	0.72	4/20
SCHEMBL3649628	0.72	4/20
SCHEMBL3647639	0.71	4/20
SCHEMBL3647429	0.70	4/20
SCHEMBL3648592	0.69	4/20
SCHEMBL3644447	0.68	4/20
SCHEMBL3644376	0.67	4/20
SCHEMBL3643465	0.66	4/20
SCHEMBL3647844	0.65	4/20
SCHEMBL3648856	0.64	4/20
SCHEMBL3643984	0.64	4/20
SCHEMBL3643988	0.64	4/20
SCHEMBL3649404	0.64	4/20
SCHEMBL3646906	0.63	4/20
SCHEMBL3646908	0.63	4/20
SCHEMBL3649289	0.63	4/20
SCHEMBL3643778	0.62	4/20
SCHEMBL3647315	0.62	4/20
SCHEMBL3644896	0.61	4/20

Clinical trials — most relevant to DKK1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis	PHASE4	COMPLETED
The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels	PHASE4	UNKNOWN
ACE Reno, Pico Cell Matrix and Its Effect on eGFR in Chronic Kidney Diseases	PHASE4	RECRUITING
Vitamin k1 and Its Relation to Vascular Calcification in Hemodialysis Patients	PHASE4	COMPLETED
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands	PHASE1	COMPLETED
Phase 1 Study to Evaluate the Safety, Tolerability and Pharmacokinetic Profile of XNW7201 in Subjects With Advanced Solid Tumors	PHASE1	COMPLETED
Non Invasive Assessment of Heart Failure	EARLY_PHASE1	UNKNOWN
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury	nan	UNKNOWN
Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis	nan	RECRUITING
DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in Periodontitis Patients With and Without CAD	nan	UNKNOWN
Homburg Renal Evaluation Study on the Clinical Utility of Early AKI Diagnosis	nan	RECRUITING
DKK3 for Prognosis and Monitoring of GFR Decline in Heart Failure	nan	COMPLETED
The Use of Urinary Dickkopf 3 (u DKK3) as a New Biomarker Which Can Identify Patients at High Risk of Renal Allograft Dysfunction, Earlier That the Current Established Tests.	nan	NOT_YET_RECRUITING
Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment	nan	COMPLETED
Serum Dickkopf-4 as a Biomarker for the Diagnosis and Treatment of Gastrointestinal Stromal Tumor	nan	UNKNOWN
Klotho _ LRP-6 _ Gastric Adenocarcinoma	nan	UNKNOWN
Cycling Duration and Bone Markers in in Active Young Adults	nan	WITHDRAWN
Serum Sclerostin Levels, Cardiovascular Parameters and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients	nan	UNKNOWN
Planetary Habitat Simulation: Bone Metabolism Studies	nan	COMPLETED
Osteogenic Effects in Human Mesenchymal Stem Cells Enhanced by Wnt Signaling	nan	COMPLETED
Biomarkers of AKI in Patients Receiving Daratumumab	nan	COMPLETED
Assessment of ProEnkephalin to Detect Acute Kidney Injury (AKI)	nan	COMPLETED
The Effects of Hemodialysis on Serum Sclerostin Levels	nan	COMPLETED
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Sclerostin and Vascular Calcification in CKD and Renal Transplant	nan	UNKNOWN
Role of Podocan and Wnt Pathway Regulatory Molecules in Coronary Artery Disease	nan	COMPLETED
Abnormal 3-D MRI Flow Patterns in Adolescents Patients With Bicuspid Aortic Valve	nan	COMPLETED
The Bone-parathyroid Crosstalk in Primary Hyperparathyroidism	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DKK1 binder may also engage these)

Protein	Name	Similarity
O54908	—	0.998	O54908 →
Q9UBU2	—	0.985	Q9UBU2 →
Q9QYZ8	—	0.985	Q9QYZ8 →
Q8VEJ3	—	0.979	Q8VEJ3 →
Q9UBT3	—	0.974	Q9UBT3 →
Q9W7R4	—	0.973	Q9W7R4 →
P47877	—	0.972	P47877 →
IGFBP5	Insulin-like growth factor-binding protein 5	0.972	landscape →
Q86TH1	—	0.971	Q86TH1 →
Q5EGE1	—	0.971	Q5EGE1 →
P24853	—	0.971	P24853 →
P24594	—	0.970	P24594 →
Q68FM6	—	0.969	Q68FM6 →
Q29400	—	0.969	Q29400 →
IGFBP2	Insulin-like growth factor-binding protein 2	0.968	landscape →
Q2TJ95	—	0.968	Q2TJ95 →
Q5R5D2	—	0.968	Q5R5D2 →
Q9WTS6	—	0.968	Q9WTS6 →
Q28985	—	0.967	Q28985 →
Q8AVH7	—	0.967	Q8AVH7 →
IGFBP3	Insulin-like growth factor-binding protein 3	0.966	landscape →
Q7TSK7	—	0.966	Q7TSK7 →
Q6X4U4	—	0.966	Q6X4U4 →
Q91V88	—	0.966	Q91V88 →
Q5XHC5	—	0.966	Q5XHC5 →
P47878	—	0.966	P47878 →
Q8JG33	—	0.965	Q8JG33 →
O75129	—	0.965	O75129 →
P13384	—	0.965	P13384 →
P12843	—	0.965	P12843 →