Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IL18 | Q14116 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18808793 | 0.83 | PDE4B (0.47) | KDM4EPDE4BSCN9ACYP11B1CYP11B2 | |
| SCHEMBL22053375 | 0.81 | PARP15 (0.46) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL29878722 | 0.80 | PARP15 (0.45) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL22054378 | 0.80 | PARP15 (0.45) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL20476347 | 0.79 | PARP15 (0.47) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL10268046 | 0.79 | PARP15 (0.44) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL595139 | 0.79 | PARP15 (0.44) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL28863087 | 0.79 | PARP15 (0.44) | PARP15PARP10PARP2KDM4EMEN1 | |
| SCHEMBL18809379 | 0.78 | POLB (0.48) | POLBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL19622198 | 0.78 | AR (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246034-A1 | BORON-CONTAINING SMALL MOLECULES AS ANTI-INFLAMMATORY AGENTS | Anacor Pharmaceuticals, Inc. (US) | 2017-11-22 | — | — | EP | disclosed |
| EP-2564857-B1 | Boron-containing small molecules as anti-inflammatory agents | ANACOR PHARMACEUTICALS INC (US) | 2017-05-03 | — | — | EP | disclosed |