Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12282452 | 0.79 | KDM4C (0.46) | KDM4EKMT2ANOS2MEN1NOS1 | |
| SCHEMBL14367970 | 0.78 | UHRF1 (0.48) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL13403895 | 0.77 | KDR (0.48) | — | |
| SCHEMBL21475739 | 0.77 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL171083 | 0.77 | CTSA (0.48) | UHRF1CCR1CCR5CCR8FDPS | |
| SCHEMBL29580736 | 0.77 | CTSA (0.48) | UHRF1CCR1CCR5CCR8FDPS | |
| SCHEMBL26528884 | 0.77 | CBLB (0.34) | ALDH1A1CSF1RFLT3NPC1RAB9A | |
| SCHEMBL27268194 | 0.76 | UHRF1 (0.46) | UHRF1CCR1CCR5CCR8KDM4E | |
| SCHEMBL25898606 | 0.75 | NOS3 (0.44) | NOS2NOS3ALDH1A1L3MBTL1LMNA | |
| SCHEMBL23416482 | 0.74 | UHRF1 (0.45) | UHRF1CCR1CCR5CCR8KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675274-B1 | SORAFENIB DERIVATIVES AS sEH INHIBITORS | UNIV CALIFORNIA (US) | 2017-05-03 | — | — | EP | disclosed |