Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.44 |
| ▸ | BCL6 | P41182 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786648 | 0.74 | MKNK1 (0.77) | MKNK2MKNK1 | |
| SCHEMBL18789173 | 0.65 | MKNK2 (1.00) | MKNK2MKNK1 | |
| SCHEMBL20010877 | 0.64 | MKNK2 (0.64) | MKNK2MKNK1 | |
| SCHEMBL18786662 | 0.60 | MKNK2 (0.50) | MKNK2MKNK1BCL6 | |
| SCHEMBL18819413 | 0.59 | MKNK2 (0.33) | MKNK2MKNK1 | |
| SCHEMBL18789169 | 0.55 | MKNK2 (1.00) | MKNK2MKNK1 | |
| SCHEMBL18786615 | 0.54 | MKNK1 (1.00) | MKNK2MKNK1 | |
| SCHEMBL28059383 | 0.54 | HPGDS (0.49) | — | |
| SCHEMBL26667125 | 0.54 | CDC25B (0.34) | — | |
| SCHEMBL23727834 | 0.51 | MKNK2 (0.38) | MKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017075412-A1 | PYRROLO-, PYRAZOLO-, IMIDAZO-PYRIMIDINE AND PYRIDINE COMPOUNDS THAT INHIBIT MNK1 AND MNK2 | EFFECTOR THERAPEUTICS, INC. (US) | 2017-05-04 | — | — | WO | disclosed |