Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 11/20 | 0.58 |
| ▸ | GSK3A | P49840 | 5/20 | 0.52 |
| ▸ | GSK3B | P49841 | 5/20 | 0.52 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCND2 | P30279 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830111 | 0.94 | MAPK6 (0.56) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| Carbamic Acid SCHEMBL18813058 | 0.91 | MAPK6 (0.65) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| Carbamic Acid SCHEMBL18813021 | 0.89 | MAPK6 (0.67) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL16011979 | 0.88 | MAPK6 (0.66) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL18830110 | 0.88 | MAPK6 (0.66) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| Carbamic Acid SCHEMBL18813100 | 0.84 | MAPK6 (0.57) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18813047 | 0.84 | MAPK6 (0.63) | MAPK6GSK3AGSK3BEIF2AK4AURKA | |
| SCHEMBL17435403 | 0.84 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4CDK2 | |
| SCHEMBL18830636 | 0.84 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4CDK2 | |
| SCHEMBL16012117 | 0.84 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | claimed |