Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 11/20 | 0.56 |
| ▸ | GSK3A | P49840 | 3/20 | 0.53 |
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbamic Acid SCHEMBL18813065 | 0.94 | MAPK6 (0.58) | MAPK6GSK3AGSK3BEIF2AK4CDK4 | |
| SCHEMBL18830423 | 0.88 | MAPK6 (0.67) | MAPK6GSK3AGSK3BEIF2AK4CDK4 | |
| SCHEMBL16012118 | 0.88 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL16012117 | 0.88 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL18830636 | 0.88 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL17435403 | 0.88 | GSK3A (0.59) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL18830110 | 0.84 | MAPK6 (0.66) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| SCHEMBL16011979 | 0.84 | MAPK6 (0.66) | MAPK6GSK3AGSK3BEIF2AK4SYK | |
| Carbamic Acid SCHEMBL18813058 | 0.84 | MAPK6 (0.65) | MAPK6GSK3AGSK3BEIF2AK4MAPK8 | |
| SCHEMBL18830106 | 0.82 | MAPK6 (0.53) | MAPK6GSK3AGSK3BEIF2AK4MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |