Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 12/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | MAPK6 | Q16659 | 6/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18813078 | 0.91 | GSK3A (0.44) | EIF2AK4GSK3AGSK3BMAPK6BMPR1B | |
| SCHEMBL17446332 | 0.88 | EIF2AK4 (0.60) | EIF2AK4GSK3AGSK3BMAPK6 | |
| Bicarbonate SCHEMBL18813060 | 0.86 | GSK3A (0.57) | EIF2AK4GSK3AGSK3BMAPK6 | |
| Carbamic Acid SCHEMBL18813026 | 0.85 | GSK3A (0.56) | EIF2AK4GSK3AGSK3BMAPK6 | |
| SCHEMBL18813105 | 0.85 | MAPK6 (0.62) | EIF2AK4GSK3AGSK3BMAPK6BMPR1B | |
| SCHEMBL18830216 | 0.83 | GSK3A (0.57) | EIF2AK4GSK3AGSK3BMAPK6 | |
| SCHEMBL16014926 | 0.83 | EIF2AK4 (0.47) | EIF2AK4GSK3AGSK3BMAPK6 | |
| SCHEMBL16014928 | 0.83 | EIF2AK4 (0.47) | EIF2AK4GSK3AGSK3BMAPK6 | |
| SCHEMBL18813076 | 0.80 | MAPK6 (0.49) | EIF2AK4GSK3AGSK3BMAPK6 | |
| SCHEMBL18813039 | 0.79 | MAPK6 (0.46) | EIF2AK4GSK3AGSK3BMAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | claimed |