SCHEMBL188145

SCHEMBL188145

CCCCCCCCCCCCCCCCCC=CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)(O)OP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)(O)O

nearest known ligand 0.80

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
NAA50 Q9GZZ1 2/20 0.80
CHAT P28329 2/20 0.76
EP300 Q09472 4/20 0.75
KAT5 Q92993 2/20 0.75
AURKA O14965 2/20 0.75
KAT2B Q92831 1/20 0.75
CREBBP Q92793 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1590966 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL2510587 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL188713 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL14836951 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL1331291 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL19181352 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL2513740 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL188242 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL6061352 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA
SCHEMBL31338605 1.00 NAA50 (0.80) NAA50CHATEP300KAT5AURKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2401696-B1 MAMMALIAN CELL LINE MODELS AND RELATED METHODS INTREXON CEU INC (US) 2017-06-21 EP disclosed
US-20160364520-A1 MAMMALIAN CELL LINE MODELS AND RELATED METHODS GENOMATICA, INC. 2016-12-15 US disclosed
US-9454640-B2 Mammalian cell line models and related methods INTREXON CEU, INC. (US) 2016-09-27 US disclosed
US-20120191434-A1 ARTICLES OF MANUFACTURE AND METHODS FOR MODELING CHINESE HAMSTER OVARY (CHO) CELL METABOLISM GT LIFE SCIENCES, INC. (US) 2012-07-26 US disclosed
US-20120185226-A1 MAMMALIAN CELL LINE MODELS AND RELATED METHODS GENOMATICA, INC. (US) 2012-07-19 US disclosed
US-8124835-B2 Acyl-coa-dependent diacylglycerol acyltransferas 1 (DGAT1) gene from Tropaeolum majus, protein encoded thereby and uses thereof NATIONAL RESEARCH COUNCIL OF CANADA 2012-02-28 US disclosed
EP-2401696-A1 MAMMALIAN CELL LINE MODELS AND RELATED METHODS GT Life Sciences, Inc. (US) 2012-01-04 EP disclosed
WO-2010098865-A1 MAMMALIAN CELL LINE MODELS AND RELATED METHODS GT LIFE SCIENCES, INC. (US) 2010-09-02 WO disclosed
US-20090293145-A1 Acyl-coa-dependent diacylglycerol acyltransferas 1 (dgat1) gene from tropaeolum majus, protein encoded thereby and uses thereof NATIONAL RESEARCH COUNCIL OF CANADA (CA) 2009-11-26 US disclosed
EP-1699927-A4 FATTY ACID ELONGASE (FAE) GENES AND THEIR UTILITY IN INCREASING ERUCIC ACID AND OTHER VERY LONG-CHAIN FATTY ACID PROPORTIONS IN SEED OIL CA NAT RESEARCH COUNCIL (CA) 2009-05-06 EP disclosed
WO-1998055631-A1 DIACYLGLYCEROL ACYL TRANSFERASE PROTEINS CALGENE LLC (US) 1998-12-10 WO disclosed
US-5723747-A Wax esters in transformed plants CALGENE, INC. (US) 1998-03-03 US disclosed
US-5679881-A FREE FROM INTACT PLANT CELLS; CAPABLE OF CATALYZING PRODUCTION OF VERY LONG CHAIN FATTY ACIDS CALGENE, INC. (US) 1997-10-21 US disclosed
EP-0731840-A1 NUCLEIC ACID SEQUENCES ENCODING A PLANT CYTOPLASMIC PROTEIN INVOLVED IN FATTY ACYL-COA METABOLISM CALGENE, INC. (US) 1996-09-18 EP disclosed
EP-0711351-A1 WAX ESTERS IN TRANSFORMED PLANTS CALGENE, INC. (US) 1996-05-15 EP disclosed
WO-1995033055-A2 WAX ESTERS IN TRANSFORMED PLANTS CALGENE INC. (US) 1995-12-07 WO disclosed
US-5445947-A Jojoba wax biosynthesis gene CALGENE INC. (US) 1995-08-29 US disclosed
WO-1995015387-A2 NUCLEIC ACID SEQUENCES ENCODING A PLANT CYTOPLASMIC PROTEIN INVOLVED IN FATTY ACYL-COA METABOLISM CALGENE, INC. (US) 1995-06-08 WO disclosed
EP-0572603-A1 FATTY ACYL-CoA: FATTY ALCOHOL O-ACYLTRANSFERASES CALGENE, INC. (US) 1993-12-08 EP disclosed
WO-1993010241-A1 FATTY ACYL-CoA: FATTY ALCOHOL O-ACYLTRANSFERASES CALGENE, INC. (US) 1993-05-27 WO disclosed