NAA50 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL2727218	0.36	5/20
SCHEMBL2726484	0.39	4/20
SCHEMBL6466478	0.38	4/20
SCHEMBL4423533	0.52	3/20
SCHEMBL4284018	0.39	3/20
SCHEMBL4817595	0.39	3/20
SCHEMBL4817606	0.39	3/20
SCHEMBL1174267	0.37	3/20
SCHEMBL6413925	0.36	3/20
SCHEMBL6086	1.00	2/20
Coenzyme_A (SCHEMBL26752)	1.00	2/20
Coenzyme_A (SCHEMBL26753)	1.00	2/20
SCHEMBL822955	1.00	2/20
SCHEMBL4356277	1.00	2/20
SCHEMBL4356293	1.00	2/20
Charcoal, Activated (SCHEMBL1644139)	0.99	2/20
SCHEMBL3503173	0.99	2/20
Isopropyl Alcohol (SCHEMBL1514614)	0.98	2/20
Acetic Acid (SCHEMBL6049904)	0.98	2/20
Pyruvate (SCHEMBL1207562)	0.96	2/20

Clinical trials — most relevant to NAA50 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Sirtuin-NAD Activator in Alzheimer's Disease	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Multicenter Study of NAP (AL-108) in Schizophrenia	PHASE2	COMPLETED
Effects of Vitamin B3 in Patients With Ataxia Telangiectasia	PHASE2	COMPLETED
NAD Supplementation to Prevent Progressive Neurological Disease in Ataxia Telangiectasia	PHASE2	ACTIVE_NOT_RECRUITING
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma	PHASE1/PHASE2	COMPLETED
PhII 5-Azacytidine Plus Valproic Acid and Eventually Atra in Intermediate II and High Risk MDS	PHASE2	COMPLETED
An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab	PHASE1/PHASE2	RECRUITING
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy	PHASE2	ACTIVE_NOT_RECRUITING
Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome	PHASE1	COMPLETED
Gene Therapy for Alzheimer's Disease Clinical Trial	PHASE1	COMPLETED
Choline Effects - Pre-symptomatic AD	PHASE1	COMPLETED
Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid	EARLY_PHASE1	COMPLETED
Southeastern ATTR Amyloidosis Consortium: SEATTRAC Family Registry	nan	NOT_YET_RECRUITING
Molecular Studies on the Candidate Genes of Dopaminergic and Noradrenergic Systems in ADHD	nan	COMPLETED
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants.	nan	UNKNOWN
Thermogenic Silencer Regulatory Factors in Humans	nan	ACTIVE_NOT_RECRUITING
Induced Pluripotent Stem Cells for Niemann Pick Disease	nan	COMPLETED
Biomarker for Niemann Pick Type C Disease (BioNPC)	nan	WITHDRAWN
Investigate eNAMPT in Multiple Myeloma Biology and Establish Its Role in Disease Progression	nan	COMPLETED
Effect of Exercise Gene Expression and Histone Modifications in Patients With Hemiplegia	nan	RECRUITING
Lipa Gene Mutation in PED-LIPIGEN (Pediatric FH Subjects)	nan	UNKNOWN
Using Next-generation Sequencing in the Diagnosis of Epilepsy and/or Intellectual Disability in a Pediatric Cohorte	nan	COMPLETED
Identification of New FTLD Genes	nan	UNKNOWN
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Contribution of Functional MRI in Assessment of Auditory Processing Disorders	nan	COMPLETED
Memantine and Down's Syndrome	nan	UNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
Multi-modal Neuroimaging in Alzheimer's Disease IMAP+	nan	COMPLETED
Blood Sample Donations to Study the Role of Genes in Pain	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NAA50 binder may also engage these)

Protein	Name	Similarity
Q5RF28	—	1.000	Q5RF28 →
Q6PGB6	—	1.000	Q6PGB6 →
Q6DBY2	—	1.000	Q6DBY2 →
Q0IIJ0	—	1.000	Q0IIJ0 →
Q6GP53	—	1.000	Q6GP53 →
Q5XGA9	—	1.000	Q5XGA9 →
Q9NHD5	—	0.972	Q9NHD5 →
Q9UTI3	—	0.945	Q9UTI3 →
Q8SSN5	—	0.941	Q8SSN5 →
Q52PH6	—	0.941	Q52PH6 →
A1IVT7	—	0.940	A1IVT7 →
Q8LGI8	—	0.940	Q8LGI8 →
P25911	—	0.939	P25911 →
Q4W6D3	—	0.939	Q4W6D3 →
G1XJZ4	—	0.939	G1XJZ4 →
Q96EK6	—	0.939	Q96EK6 →
Q4WSF6	—	0.938	Q4WSF6 →
Q8NJT7	—	0.938	Q8NJT7 →
Q09892	—	0.938	Q09892 →
Q6PWX2	—	0.937	Q6PWX2 →
A3EZ55	—	0.937	A3EZ55 →
A2QRF6	—	0.937	A2QRF6 →
Q875L0	—	0.937	Q875L0 →
Q96TL5	—	0.937	Q96TL5 →
Q9UV51	—	0.937	Q9UV51 →
Q4PC06	—	0.937	Q4PC06 →
Q53H82	—	0.937	Q53H82 →
A0A7U2QYM2	—	0.936	A0A7U2QYM2 →
Q2WFL5	—	0.936	Q2WFL5 →
A1CPG7	—	0.936	A1CPG7 →