Efletirizine

Efletirizine

SCHEMBL18816

O=C(O)COCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 4/20 0.72
TDP1 Q9NUW8 2/20 0.72
HRH2 P25021 2/20 0.72
HTR2A P28223 2/20 0.72
DRD3 P35462 2/20 0.72
HTR2B P41595 2/20 0.72
KCNH2 Q12809 2/20 0.72
USP2 O75604 2/20 0.72
SLC6A2 P23975 1/20 0.72
SLC6A4 P31645 1/20 0.72
SLC6A3 Q01959 1/20 0.72
TEK Q02763 1/20 0.72
ACHE P22303 3/20 0.58
ALDH1A1 P00352 1/20 0.54
LMNA P02545 1/20 0.54
GAA P10253 1/20 0.54
MAPT P10636 1/20 0.54
MAPK1 P28482 1/20 0.54
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Efletirizine SCHEMBL3882700 0.99 HRH1 (0.73) HRH1TDP1HRH2HTR2ADRD3
Efletirizine SCHEMBL1691233 0.99 HRH1 (0.73) HRH1TDP1HRH2HTR2ADRD3
Efletirizine SCHEMBL8211713 0.99 HRH1 (0.71) HRH1TDP1HRH2HTR2ADRD3
Efletirizine SCHEMBL3874525 0.97 HRH1 (0.71) HRH1TDP1HRH2HTR2ADRD3
SCHEMBL10932667 0.97 HRH1 (0.69) HRH1TDP1HRH2HTR2ADRD3
SCHEMBL2058738 0.96 HRH1 (0.79) HRH1TDP1HRH2HTR2ADRD3
Water SCHEMBL10930897 0.95 HRH1 (0.77) HRH1TDP1HRH2HTR2ADRD3
Efletirizine SCHEMBL5794933 0.92 HRH1 (0.65) HRH1TDP1HRH2HTR2ADRD3
Efletirizine SCHEMBL5797969 0.92 HRH1 (0.65) HRH1TDP1HRH2HTR2ADRD3
Efletirizine SCHEMBL5794985 0.89 HRH1 (0.61) HRH1TDP1HRH2HTR2ADRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1872 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111012734-B Drug-loaded reticular in-situ phase-change gel sustained-release system and preparation method thereof 四川大学 2021-08-20 CN claimed
EP-3400971-B1 ABSORBABLE IRON-BASED ALLOY IMPLANTABLE MEDICAL DEVICE BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2021-08-04 EP claimed
EP-3400969-B1 IMPLANTED DEVICE BIOTYX MEDICAL SHENZHEN CO LTD (CN) 2021-05-19 EP claimed
CN-110876711-B Method for preparing multilayer polymer microneedle 北京化工大学 2021-03-26 CN claimed
US-10946121-B2 Absorbable iron-based alloy implantable medical device BIOTYX MEDICAL (SHENZHEN) CO., LTD. (CN) 2021-03-16 US claimed
EP-3400970-B1 ABSORBABLE IRON-BASED ALLOY MEDICAL DEVICE IMPLANT LIFETECH SCIENT SHENZHEN CO (CN) 2021-03-03 EP claimed
CN-107049932-B Small molecule drug in-situ phase change gel sustained release system and preparation method thereof 四川大学 2020-11-06 CN claimed
US-20200215237-A1 ABSORBABLE IRON-BASED ALLOY IMPLANTABLE MEDICAL DEVICE BIOTYX MEDICAL (SHENZHEN) CO., LTD. (CN) 2020-07-09 US claimed
EP-3643298-A1 IN SITU PHASE CHANGE GEL SUSTAINED-RELEASE SYSTEM FOR SMALL MOLECULE DRUG AND PREPARATION METHOD THEREOF Sichuan University (CN) 2020-04-29 EP claimed
CN-106806938-B Absorbable iron-based alloy implantation medical instrument 先健科技(深圳)有限公司 2020-04-14 CN claimed
US-6103735-A IN COMBINATION, ANTAGONISTS OF A NEUORKININ, A HISTAMINE 3 AND A HISTAMINE 1; ANTIALLERGENS; RHINITIS, ASTHMA AND RELATED DISORDERS; COUGH, WHEEZING; SNEEZING, ITCHING, RUNNY NOSE, NASAL CONGESTION, REDNESS OF THE EYE, TEARING SCHERING CORPORATION (US) 2000-08-15 US claimed
WO-2000021512-A2 COMPOSITION AND METHOD FOR TREATING ALLERGIC DISEASES SCHERING CORPORATION (US) 2000-04-20 WO claimed
CN-1250371-A Pharmaceutical composition for the controlled release of active substances UCB SA (BE) 2000-04-12 CN claimed
CN-1233179-A Treatment of upper airway allergic responses with a combination of histamine receptor antagonists SCHERING CORP (US) 1999-10-27 CN claimed
WO-1999032125-A1 COMPOSITION FOR TREATING RESPIRATORY AND SKIN DISEASES, COMPRISING AT LEAST ONE LEUKOTRIENE ANTAGONIST AND AT LEAST ONE ANTIHISTAMINE SCHERING CORPORATION (US) 1999-07-01 WO claimed
EP-0920315-A1 TREATMENT OF UPPER AIRWAY ALLERGIC RESPONSES WITH A COMBINATION OF HISTAMINE RECEPTOR ANTAGONISTS SCHERING CORPORATION (US) 1999-06-09 EP claimed
WO-1999015203-A1 USE OF COMBINATIONS COMPRISING NON-SEDATING ANTIHISTAMINES AND ALPHA-ADRENERGIC DRUGS FOR THE TOPICAL TREATMENT OF RHINITIS/CONJUNCTIVITIS AND COLD, COLD-LIKE AND/OR FLU SYMPTOMS ASTA MEDICA AKTIENGESELLSCHAFT (DE) 1999-04-01 WO claimed
EP-0903151-A1 Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms ASTA Medica Aktiengesellschaft (DE) 1999-03-24 EP claimed
US-5869479-A ADMINISTERING HISTAMINE H1 RECEPTOR ANTAGONISTS AND HISTAMINE H3 RECEPTOR ANTAGONISTS; NASAL DECONGESTANT WITHOUT THE NERVOUS SYSTEM OR CARDIOVASCULAR SIDE EFFECTS SCHERING CORPORATION (US) 1999-02-09 US claimed
WO-1998006394-A1 TREATMENT OF UPPER AIRWAY ALLERGIC RESPONSES WITH A COMBINATION OF HISTAMINE RECEPTOR ANTAGONISTS SCHERING CORPORATION (US) 1998-02-19 WO claimed