Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.79 |
| ▸ | HRH2 | P25021 | 2/20 | 0.79 |
| ▸ | HTR2A | P28223 | 2/20 | 0.79 |
| ▸ | DRD3 | P35462 | 2/20 | 0.79 |
| ▸ | HTR2B | P41595 | 2/20 | 0.79 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.79 |
| ▸ | USP2 | O75604 | 2/20 | 0.79 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.79 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.79 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.79 |
| ▸ | TEK | Q02763 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10930897 | 0.99 | HRH1 (0.77) | HRH1TDP1HRH2HTR2ADRD3 | |
| Efletirizine SCHEMBL18816 | 0.96 | HRH1 (0.72) | HRH1TDP1HRH2HTR2ADRD3 | |
| Efletirizine SCHEMBL8211713 | 0.95 | HRH1 (0.71) | HRH1TDP1HRH2HTR2ADRD3 | |
| Efletirizine SCHEMBL1691233 | 0.95 | HRH1 (0.73) | HRH1TDP1HRH2HTR2ADRD3 | |
| Efletirizine SCHEMBL3882700 | 0.95 | HRH1 (0.73) | HRH1TDP1HRH2HTR2ADRD3 | |
| Efletirizine SCHEMBL3874525 | 0.94 | HRH1 (0.71) | HRH1TDP1HRH2HTR2ADRD3 | |
| SCHEMBL10932667 | 0.94 | HRH1 (0.69) | HRH1TDP1HRH2HTR2ADRD3 | |
| SCHEMBL2058840 | 0.93 | HRH1 (0.86) | HRH1TDP1HRH2HTR2ADRD3 | |
| SCHEMBL10932202 | 0.91 | HRH1 (0.65) | HRH1TDP1HRH2HTR2ADRD3 | |
| SCHEMBL2058530 | 0.90 | HRH1 (0.82) | HRH1TDP1HRH2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6469009-B1 | MIXTURE CONSISTING ESSENTIALLY OF PSEUDOEPHEDRINE AND COMPOUND SELECTED FROM 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACID OR AMIDE DERIVATIVES, THEIR INDIVIDUAL OPTICAL ISOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS | UCB, S.A. (BE) | 2002-10-22 | — | — | US | claimed |
| US-20010020023-A1 | Pharmaceutical compositions for the treatment of rhinitis | UCB PHARMA, S.A. (BE) | 2001-09-06 | — | — | US | claimed |
| US-4525358-A | ANTIHISTAMINES, ANTIALLERGENS, ANTISPASMODICS, BRONCHODILATORS | UCB PHARMACEUTICALS, INC. (US) | 1985-06-25 | — | — | US | claimed |
| EP-0058146-B1 | 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACIDS AND THEIR AMIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | U C B, S.A. (BE) | 1984-06-27 | — | — | EP | claimed |
| US-7968549-B2 | Diarylmethylpiperazines as therapeutic agents for viral myocarditis | MATSUMORI AKIRA | 2011-06-28 | — | — | US | disclosed |
| WO-2010081036-A2 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-07-15 | — | — | WO | disclosed |
| US-20070281947-A1 | Diarylmethylpiperazines As Prophylactic Or Therapeutic Agents For Viral Myocarditis | UCB FARCHIM SA (CH) | 2007-12-06 | — | — | US | disclosed |
| US-20050090454-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease | EPIGENESIS PHARMACEUTICALS, LLC | 2005-04-28 | — | — | US | disclosed |
| WO-2005011604-A2 | COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH AN ANTIHISTAMINE FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE | EPIGENESIS PHARMACEUTICALS LLC (US) | 2005-02-10 | — | — | WO | disclosed |
| US-20050026890-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease | EPIGENESIS PHARMACEUTICALS LLC | 2005-02-03 | — | — | US | disclosed |
| US-6489329-B2 | MIXTURE OF PSEUDOEPHEDRINE AND 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)ACETIC ACID | UCB S.A. (BE) | 2002-12-03 | — | — | US | disclosed |
| US-6469009-B1 | MIXTURE CONSISTING ESSENTIALLY OF PSEUDOEPHEDRINE AND COMPOUND SELECTED FROM 2-(4-(DIPHENYLMETHYL)-1-PIPERAZINYL)-ACETIC ACID OR AMIDE DERIVATIVES, THEIR INDIVIDUAL OPTICAL ISOMERS OR PHARMACEUTICALLY ACCEPTABLE SALTS | UCB, S.A. (BE) | 2002-10-22 | — | — | US | disclosed |
| US-20010020023-A1 | Pharmaceutical compositions for the treatment of rhinitis | UCB PHARMA, S.A. (BE) | 2001-09-06 | — | — | US | disclosed |
| EP-1014983-A1 | NAPROXEN/CETIRIZINE COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY DISORDERS | THE PROCTER & GAMBLE COMPANY (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999015173-A1 | COMPOSITIONS AND METHODS FOR TREATING RESPIRATORY DISORDERS | THE PROCTER & GAMBLE COMPANY (US) | 1999-04-01 | — | — | WO | disclosed |
| US-4525358-A | ANTIHISTAMINES, ANTIALLERGENS, ANTISPASMODICS, BRONCHODILATORS | UCB PHARMACEUTICALS, INC. (US) | 1985-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070281947-A1 | Diarylmethylpiperazines As Prophylactic Or Therapeutic Agents For Viral Myocarditis | ACE2, TNNT2, MYLK2 | HRH1 575/4885TDP1 2017/4885HRH2 265/4885 |
| US-20050026890-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease | KIT, HSD11B2, HSD3B1 | HRH1 26/4885TDP1 4382/4885HRH2 40/4885 |
| US-20010020023-A1 | Pharmaceutical compositions for the treatment of rhinitis | HRH4, HRH2, HRH1 | HRH1 3/4885TDP1 4206/4885HRH2 2/4885 |
| US-20050090454-A1 | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease | KIT, HSD11B2, HSD3B1 | HRH1 28/4885TDP1 4491/4885HRH2 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.