Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 10/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TOP2A | P11388 | 4/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13830897 | 0.88 | NISCH (0.56) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL18824741 | 0.81 | NISCH (0.50) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL18824746 | 0.75 | NISCH (0.60) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL13830922 | 0.75 | NISCH (0.58) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL13831444 | 0.70 | NISCH (0.77) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL13830691 | 0.70 | NISCH (0.55) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL18824711 | 0.70 | NISCH (0.55) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL13830762 | 0.70 | NISCH (0.49) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL13831194 | 0.70 | NISCH (0.55) | NISCHGAATSHRTOP2ATOP2B | |
| SCHEMBL14029044 | 0.68 | NISCH (0.75) | NISCHGAATSHRTOP2ATOP2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11801251-B2 | Selective HDAC8 inhibitors and their uses | HOCHSCHULE DARMSTADT (DE) | 2023-10-31 | — | — | US | disclosed |
| US-20210220370-A1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | HOCHSCHULE DARMSTADT (DE) | 2021-07-22 | — | — | US | disclosed |
| EP-3371195-B1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | HOCHSCHULE DARMSTADT (DE) | 2021-04-21 | — | — | EP | disclosed |
| US-20180311257-A1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | HOCHSCHULE DARMSTADT (DE) | 2018-11-01 | — | — | US | disclosed |
| EP-3371195-A1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | Hochschule Darmstadt (DE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017077008-A1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | HOCHSCHULE DARMSTADT (DE) | 2017-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180311257-A1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | HDAC8, HDAC5, HDAC7 | NISCH 3504/4885GAA 278/4885TSHR 3718/4885 |
| US-11801251-B2 | Selective HDAC8 inhibitors and their uses | HDAC8, HDAC5, HDAC7 | NISCH 3504/4885GAA 278/4885TSHR 3718/4885 |
| US-20210220370-A1 | SELECTIVE HDAC8 INHIBITORS AND THEIR USES | HDAC8, HDAC5, HDAC7 | NISCH 3504/4885GAA 278/4885TSHR 3718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.