Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 9/20 | 0.46 |
| ▸ | ATR | Q13535 | 7/20 | 0.46 |
| ▸ | MTOR | P42345 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824740 | 1.00 | ATM (0.46) | ATMATRMTORPIK3CATLR9 | |
| SCHEMBL18824981 | 0.96 | ATM (0.45) | ATMATRMTORPIK3CATLR9 | |
| SCHEMBL18824979 | 0.96 | ATM (0.45) | ATMATRMTORPIK3CATLR9 | |
| SCHEMBL18824749 | 0.89 | ATM (0.50) | ATMATRMTORPIK3CATLR9 | |
| SCHEMBL18824950 | 0.86 | ATM (0.48) | ATMATRMTORPIK3CATLR9 | |
| SCHEMBL18824656 | 0.85 | ATM (0.38) | ATMATRMTORPIK3CADGAT1 | |
| SCHEMBL18824989 | 0.77 | ATM (0.61) | ATMATRMTORPIK3CATLR9 | |
| SCHEMBL18843776 | 0.75 | ATM (0.68) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL20515203 | 0.75 | ATM (0.68) | ATMATRMTORPIK3CAKCNH2 | |
| SCHEMBL18824978 | 0.74 | PARP1 (0.38) | ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3370722-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076898-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |