Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 11/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.38 |
| ▸ | MTOR | P42345 | 7/20 | 0.38 |
| ▸ | ATR | Q13535 | 5/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824743 | 0.85 | ATM (0.46) | ATMPIK3CAMTORATRDGAT1 | |
| SCHEMBL18824740 | 0.85 | ATM (0.46) | ATMPIK3CAMTORATRDGAT1 | |
| SCHEMBL18824981 | 0.84 | ATM (0.45) | ATMPIK3CAMTORATRDGAT1 | |
| SCHEMBL18824979 | 0.84 | ATM (0.45) | ATMPIK3CAMTORATRDGAT1 | |
| SCHEMBL18824749 | 0.79 | ATM (0.50) | ATMPIK3CAMTORATR | |
| SCHEMBL18824950 | 0.77 | ATM (0.48) | ATMPIK3CAMTORATR | |
| SCHEMBL20515213 | 0.76 | ATM (0.65) | ATMPIK3CAMTORATRKCNH2 | |
| SCHEMBL20515212 | 0.76 | ATM (0.65) | ATMPIK3CAMTORATRKCNH2 | |
| SCHEMBL18824714 | 0.75 | ATM (0.51) | ATMPIK3CAMTORATRKCNH2 | |
| SCHEMBL18824923 | 0.71 | ATM (0.47) | ATMPIK3CAMTORATRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3370722-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | claimed |
| WO-2017076898-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | claimed |
| EP-3370722-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017076898-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |