Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17386084 | 0.86 | CA1 (0.45) | CA1CA2SLC7A5TDP1KMT2A | |
| SCHEMBL21153821 | 0.85 | DPP4 (0.46) | SLC7A5TDP1KMT2AMEN1DPP4 | |
| SCHEMBL17386226 | 0.80 | CA1 (0.53) | CA1CA2TDP1KMT2AMAPT | |
| SCHEMBL24261200 | 0.76 | TACR1 (0.40) | KMT2AMEN1TACR1 | |
| SCHEMBL27720296 | 0.74 | CA1 (0.50) | CA1CA2KMT2AMEN1DPP4 | |
| SCHEMBL22598719 | 0.74 | NPC1 (0.46) | KMT2AMEN1DPP4MAPTLMNA | |
| SCHEMBL28597443 | 0.74 | CA1 (0.46) | CA1CA2TDP1KMT2AMEN1 | |
| SCHEMBL2667033 | 0.73 | CA1 (0.49) | CA1CA2KMT2AMEN1DPP4 | |
| SCHEMBL20622459 | 0.73 | TDP1 (0.67) | CA1CA2TDP1KMT2AMEN1 | |
| SCHEMBL20982238 | 0.73 | TDP1 (0.67) | CA1CA2TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643946-B2 | Tricyclic compound and use thereof | SK CHEMICALS CO., LTD. (KR) | 2017-05-09 | — | — | US | disclosed |