Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | MAPK6 | Q16659 | 10/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | GALR1 | P47211 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830136 | 0.98 | SYK (0.42) | SYKMAPK6CCNA2CDK2CCNA1 | |
| SCHEMBL18830257 | 0.97 | MEN1 (0.43) | SYKMAPK6CCNA2CDK2CCNA1 | |
| SCHEMBL18830434 | 0.91 | MAPK6 (0.52) | SYKMAPK6CDK2MERTK | |
| SCHEMBL18830059 | 0.90 | MAPK1 (0.43) | SYKMAPK6 | |
| SCHEMBL18830094 | 0.90 | CDK1 (0.46) | MAPK6CDK2CTSLCTSSCTSK | |
| SCHEMBL18830031 | 0.90 | MAPK6 (0.42) | SYKMAPK6MERTK | |
| SCHEMBL18830424 | 0.89 | CDK1 (0.46) | MAPK6CCNA2CDK2CCNA1AURKA | |
| SCHEMBL18830288 | 0.88 | CDK2 (0.40) | MAPK6CCNA2CDK2CCNA1AURKA | |
| SCHEMBL18830128 | 0.88 | MAPK6 (0.38) | SYKMAPK6CCNA2CDK2CCNA1 | |
| SCHEMBL18830415 | 0.87 | CDK1 (0.40) | MAPK6CCNA2CDK2CCNA1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |