Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.43 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 7/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830098 | 0.94 | MKNK1 (0.42) | MAPK1P2RX3P2RX2MKNK1MAPK6 | |
| SCHEMBL18830136 | 0.90 | SYK (0.42) | MAPK6SYK | |
| SCHEMBL18830090 | 0.90 | SYK (0.44) | MAPK6SYK | |
| SCHEMBL18830128 | 0.89 | MAPK6 (0.38) | MAPK1MKNK1MAPK6HPGDSMAPK3 | |
| SCHEMBL18830257 | 0.89 | MEN1 (0.43) | MAPK6SYK | |
| SCHEMBL18830600 | 0.89 | DRD2 (0.40) | MAPK1MAPK6 | |
| SCHEMBL18830434 | 0.88 | MAPK6 (0.52) | MAPK6MAPK8MAPK10SYK | |
| SCHEMBL18830031 | 0.87 | MAPK6 (0.42) | MAPK6HPGDSMAPK8MAPK9MAPK10 | |
| SCHEMBL18830094 | 0.87 | CDK1 (0.46) | MKNK1MAPK6HPGDSMAPK8 | |
| SCHEMBL18830424 | 0.86 | CDK1 (0.46) | MAPK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |