Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830586 | 0.87 | KDM4E (0.53) | MAPTSYKRAB9ANPC1KDM4E | |
| SCHEMBL18830446 | 0.82 | CCNT1 (0.40) | AURKASYKGAAMEN1KMT2A | |
| SCHEMBL29019893 | 0.81 | MAPT (0.55) | MAPTSMN1; SMN2AURKASYKPDPK1 | |
| SCHEMBL30394922 | 0.81 | MAPT (0.55) | MAPTSMN1; SMN2AURKASYKPDPK1 | |
| SCHEMBL18830327 | 0.81 | MAPT (0.36) | MAPTSMN1; SMN2SYKRAB9AKDM4E | |
| SCHEMBL19676002 | 0.80 | MAPT (0.54) | MAPTSMN1; SMN2AURKASYKPDPK1 | |
| SCHEMBL22719010 | 0.79 | MEN1 (0.61) | MAPTSMN1; SMN2AURKASYKPDPK1 | |
| SCHEMBL15147773 | 0.79 | MAPT (0.53) | MAPTSMN1; SMN2AURKASYKPDPK1 | |
| SCHEMBL19313055 | 0.79 | SYK (0.72) | MAPTSMN1; SMN2AURKASYKGAA | |
| SCHEMBL29535612 | 0.79 | MEN1 (0.61) | MAPTSMN1; SMN2AURKASYKPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2807161-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-10-04 | — | — | EP | disclosed |
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |