Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 8/20 | 0.43 |
| ▸ | CNR2 | P34972 | 5/20 | 0.36 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15710286 | 0.88 | EZH2 (0.42) | CSF1RCNR2CNR1 | |
| SCHEMBL15731239 | 0.81 | EZH2 (0.44) | NPC1RAB9AKMT2AOPRK1 | |
| SCHEMBL22495103 | 0.79 | EZH2 (0.49) | — | |
| SCHEMBL15710346 | 0.77 | ALDH1A1 (0.38) | CNR1KMT2APTGER4OPRK1 | |
| SCHEMBL15710364 | 0.76 | EZH2 (0.45) | CSF1RCRHR1 | |
| SCHEMBL18830443 | 0.76 | PTGER4 (0.51) | CNR2CNR1NPC1RAB9AKMT2A | |
| SCHEMBL13279921 | 0.75 | EZH2 (0.39) | CSF1RNPC1RAB9AGAAKMT2A | |
| SCHEMBL18829947 | 0.73 | CYP46A1 (0.34) | CNR2GAAKMT2A | |
| SCHEMBL13277336 | 0.73 | EZH2 (0.49) | OPRK1CRHR1 | |
| SCHEMBL18829944 | 0.72 | EZH2 (0.41) | NPC1GAAOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3470396-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2019-04-17 | — | — | EP | disclosed |
| EP-3165520-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme Inc (US) | 2017-05-10 | — | — | EP | disclosed |