Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 12/20 | 0.50 |
| ▸ | GSK3A | P49840 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16014967 | 0.86 | MAPK6 (0.61) | MAPK6GSK3AGSK3BAURKAEIF2AK4 | |
| SCHEMBL18830627 | 0.84 | MAPK6 (0.52) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL18830277 | 0.83 | MAPK6 (0.57) | MAPK6GSK3AGSK3BAURKAEIF2AK4 | |
| Carbamic Acid SCHEMBL18813033 | 0.82 | MAPK6 (0.54) | MAPK6GSK3AGSK3BAURKAEIF2AK4 | |
| SCHEMBL18830261 | 0.81 | MAPK6 (0.56) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16022138 | 0.80 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL18830615 | 0.80 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL18830192 | 0.80 | MAPK6 (0.55) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16022079 | 0.75 | MAPK6 (0.43) | MAPK6GSK3AGSK3BAURKA | |
| SCHEMBL16022270 | 0.74 | MAPK6 (0.49) | MAPK6GSK3AGSK3BAURKAEIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-B1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2017-05-10 | — | — | EP | disclosed |