Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.58 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.50 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18831943 | 1.00 | SIRT5 (0.60) | SIRT5SIRT2SIRT1SIRT3F2 | |
| SCHEMBL18873527 | 0.92 | SIRT5 (0.57) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL30527290 | 0.92 | SIRT5 (0.62) | SIRT5SIRT2SIRT1SIRT3F2 | |
| SCHEMBL25932816 | 0.92 | SIRT5 (0.62) | SIRT5SIRT2SIRT1SIRT3F2 | |
| Hydrochloric Acid SCHEMBL18831923 | 0.92 | SIRT5 (0.56) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL2268022 | 0.87 | SIRT5 (0.57) | SIRT5SIRT2SIRT1SIRT3F2 | |
| Hydrochloric Acid SCHEMBL10884941 | 0.86 | SIRT5 (0.56) | SIRT5SIRT2SIRT1SIRT3F2 | |
| SCHEMBL18099943 | 0.86 | SIRT2 (0.58) | SIRT5SIRT2SIRT1SIRT3 | |
| SCHEMBL18099942 | 0.86 | SIRT2 (0.58) | SIRT5SIRT2SIRT1SIRT3 | |
| Hydrochloric Acid SCHEMBL10943848 | 0.86 | SIRT5 (0.56) | SIRT5SIRT2SIRT1SIRT3F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650414-B1 | Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof | SIMON FRASER UNIVERSITY (CA) | 2017-05-16 | — | — | US | disclosed |