Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 11/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.51 |
| ▸ | INSR | P06213 | 2/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17410965 | 0.87 | ALK (0.74) | ALKEGFRINSRIGF1RMAP4K1 | |
| SCHEMBL18831892 | 0.85 | ALK (0.76) | ALKEGFRINSRIGF1RMET | |
| SCHEMBL18831911 | 0.82 | ALK (0.75) | ALKEGFRINSRIGF1RMAP4K1 | |
| SCHEMBL24885722 | 0.81 | ALK (0.75) | ALKEGFRINSRIGF1R | |
| SCHEMBL18831954 | 0.80 | ALK (0.76) | ALKEGFRINSRIGF1RMAP4K1 | |
| SCHEMBL25530253 | 0.78 | EGFR (0.43) | ALKEGFRINSRIGF1RMAP4K1 | |
| SCHEMBL24716379 | 0.76 | MAP4K1 (0.74) | ALKMAP4K1MET | |
| SCHEMBL21558014 | 0.76 | LRRK2 (0.55) | ALKEGFRINSRIGF1R | |
| SCHEMBL18831948 | 0.75 | ALK (0.47) | ALKEGFRINSRIGF1RMAP4K1 | |
| SCHEMBL17410967 | 0.74 | ALK (0.64) | ALKEGFRINSRIGF1RMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3165530-A1 | SPIROCYCLIC ARYL PHOSPHORUS OXIDE AND ARYL PHOSPHORUS SULFIDE | Qilu Pharmaceutical Co., Ltd (CN) | 2017-05-10 | — | — | EP | disclosed |