Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 5/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | IL2 | P60568 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130131 | 0.84 | FGFR1 (0.43) | ITKFGFR1FGFR2FGFR3KDR | |
| SCHEMBL4134571 | 0.82 | FGFR1 (0.41) | ITKFGFR1FGFR2FGFR3KDR | |
| Trifluoroacetic Acid SCHEMBL4142647 | 0.80 | FGFR1 (0.40) | ITKFGFR1FGFR2FGFR3KDR | |
| SCHEMBL4129282 | 0.80 | FGFR1 (0.43) | ITKFGFR1FGFR2FGFR3KDR | |
| SCHEMBL4124997 | 0.77 | FGFR1 (0.41) | ITKFGFR1FGFR2FGFR3KDR | |
| Trifluoroacetic Acid SCHEMBL4130036 | 0.74 | ITK (0.42) | ITKFGFR1FGFR2FGFR3KDR | |
| SCHEMBL3933348 | 0.73 | ITK (0.45) | ITKFGFR1FGFR2FGFR3KDR | |
| SCHEMBL3927781 | 0.71 | ITK (0.43) | ITKFGFR1FGFR2FGFR3KDR | |
| SCHEMBL4122389 | 0.70 | FGFR1 (0.51) | FGFR1FGFR2FGFR3KDRCDK2 | |
| Trifluoroacetic Acid SCHEMBL4130010 | 0.70 | SYK (0.43) | ITKFGFR1FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-B1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA SA (FR) | 2017-05-10 | — | — | EP | disclosed |