Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1878359 | 0.79 | MAPK14 (0.47) | MAPK14MAPKAPK2 | |
| SCHEMBL1877849 | 0.73 | MAPK14 (0.47) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL10624240 | 0.71 | L3MBTL1 (0.54) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL1882817 | 0.70 | MAPK14 (0.57) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL1879539 | 0.69 | MAPK14 (0.65) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL25344930 | 0.69 | MAPK14 (0.57) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL25343704 | 0.69 | MAPK14 (0.56) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3671793 | 0.69 | MAPK14 (0.42) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3673264 | 0.67 | MAPK14 (0.42) | MAPK14LCKKITKDRMAPKAPK2 | |
| SCHEMBL3673356 | 0.67 | MAPK14 (0.59) | MAPK14LCKKITKDRMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8435987-B2 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-8435987-B2 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-20110294805-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294805-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294805-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF | AMGEN INC. (US) | 2011-12-01 | — | — | US | disclosed |
| US-8022085-B2 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-8022085-B2 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-8022085-B2 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20110105498-A1 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105498-A1 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2011-05-05 | — | — | US | disclosed |
| US-20110105498-A1 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | AMGEN INC. (US) | 2011-05-05 | — | — | US | disclosed |
| EP-2152706-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | Amgen Inc. (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008136948-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS, PROCESS FOR THEIR PREPARATION, AND THEIR PHARMACEUTICAL USE | AMGEN INC. (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294805-A1 | PYRAZOLO-PYRIDINONE AND PYRAZOLO-PYRAZINONE COMPOUNDS AS P38 MODULATORS AND METHODS OF USE THEREOF | MAPK1, MAP4K2, MAP3K1 | MAPK14 32/4885LCK 309/4885KIT 1443/4885 |
| US-20110105498-A1 | Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof | MAPK1, MAP4K2, MAP3K1 | MAPK14 32/4885LCK 309/4885KIT 1443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.