Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 7/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17707980 | 0.81 | NPC1 (0.41) | CDK1CFTRCNR2CTSSTRPA1 | |
| SCHEMBL1858748 | 0.79 | CFTR (0.41) | CDK1CFTRCNR2CTSSTRPA1 | |
| SCHEMBL23166258 | 0.73 | KMT2A (0.39) | KDM4EHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2387153 | 0.71 | SLC22A12 (0.46) | — | |
| SCHEMBL1850824 | 0.71 | KDM4E (0.40) | KDM4EHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL4148746 | 0.70 | MEN1 (0.36) | KDM4EHPGDKMT2AMEN1NPSR1 | |
| SCHEMBL17777195 | 0.70 | CYP11B1 (0.33) | KDM4EKMT2AMEN1NPSR1 | |
| SCHEMBL3963652 | 0.69 | CTSK (0.38) | CTSKKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL30115270 | 0.69 | SMN1; SMN2 (0.39) | CDK1CFTRCTSSTRPA1KDM4E | |
| SCHEMBL25413494 | 0.69 | CFTR (0.34) | CDK1CFTRCTSSTRPA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004107-B1 | 6,7-DIHYDROPYRAZOLO[1,5-A]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-10 | — | — | EP | disclosed |