Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.45 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.45 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16028251 | 0.93 | ATM (0.48) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL19375535 | 0.87 | MAPT (0.51) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL16028545 | 0.86 | TRPC5 (0.57) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL18834564 | 0.84 | TSHR (0.53) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL16028370 | 0.83 | MAPT (0.46) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL20432232 | 0.83 | NPSR1 (0.37) | MAPTTSHRPOLBRAB9ALMNA | |
| SCHEMBL16028630 | 0.81 | TRPC5 (0.56) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL18833996 | 0.81 | TSHR (0.61) | ATMMAPTTSHRLMNAALDH1A1 | |
| SCHEMBL18834345 | 0.80 | MAPT (0.44) | ATMMAPTTSHRPOLBTRPC4 | |
| SCHEMBL16028357 | 0.79 | TRPC5 (0.60) | ATMMAPTTSHRPOLBTRPC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |