Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 11/20 | 0.43 |
| ▸ | PDE5A | O76074 | 5/20 | 0.41 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19374881 | 0.89 | P2RX3 (0.44) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL21499684 | 0.84 | P2RX3 (0.44) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL19505233 | 0.83 | P2RX3 (0.45) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL21499654 | 0.81 | P2RX3 (0.40) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL21316262 | 0.81 | P2RX3 (0.41) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL21499648 | 0.81 | TRPC4 (0.40) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL18834916 | 0.79 | TRPC4 (0.45) | P2RX3TRPC4TRPC5KCNH2TRPC1 | |
| SCHEMBL21499715 | 0.78 | P2RX3 (0.36) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL19505333 | 0.77 | P2RX3 (0.38) | P2RX3PDE5ATRPC4TRPC5KCNH2 | |
| SCHEMBL19505572 | 0.77 | TRPC4 (0.47) | P2RX3TRPC4TRPC5KCNH2TRPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |