Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 4/20 | 0.54 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.54 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 14/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16028596 | 1.00 | TRPC5 (0.54) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16079049 | 0.88 | TRPC5 (0.60) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16028314 | 0.87 | TRPC5 (0.53) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16079032 | 0.87 | TRPC5 (0.59) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16079047 | 0.86 | TRPC5 (0.54) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16076240 | 0.86 | TRPC5 (0.63) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16079033 | 0.86 | TRPC5 (0.62) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16079039 | 0.86 | TRPC5 (0.56) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16027820 | 0.85 | TRPC5 (0.73) | TRPC5TRPC4TRPC1KCNH2P2RX3 | |
| SCHEMBL16028464 | 0.85 | TRPC5 (0.57) | TRPC5TRPC4TRPC1KCNH2P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2970303-B1 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-05-10 | — | — | EP | disclosed |