Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.60 |
| ▸ | CACNA1H | O95180 | 13/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838406 | 1.00 | CACNA1I (0.60) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL29364770 | 1.00 | CACNA1I (0.60) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18838318 | 1.00 | CACNA1I (0.60) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18860299 | 0.94 | CACNA1I (0.53) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL29364436 | 0.93 | CACNA1H (0.63) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18838319 | 0.93 | CACNA1H (0.63) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18838322 | 0.93 | CACNA1H (0.63) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18838316 | 0.93 | CACNA1H (0.63) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18860180 | 0.91 | CACNA1I (0.61) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 | |
| SCHEMBL18838359 | 0.91 | CACNA1I (0.61) | CACNA1ICACNA1HCACNA1GKCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340988-B1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | AFASCI INC (US) | 2025-04-09 | — | — | EP | disclosed |
| CN-108289886-B | Ion channel inhibiting compounds, pharmaceutical formulations and uses | 安华赛公司 | 2022-01-28 | — | — | CN | disclosed |
| US-10562857-B2 | Ion channel inhibitory compounds, pharmaceutical formulations, and uses | AFASCI, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| US-10562857-B2 | Ion channel inhibitory compounds, pharmaceutical formulations, and uses | AFASCI, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| US-20180312471-A1 | Ion Channel Inhibitory Compounds, Pharmaceutical Formulations, and Uses | AFASCI, INC. (US) | 2018-11-01 | — | — | US | disclosed |
| EP-3340988-A1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | Afasci, Inc. (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017083867-A1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | AFASCI, INC. (US) | 2017-05-18 | — | — | WO | disclosed |
| WO-2017083867-A1 | ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES | AFASCI, INC. (US) | 2017-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10562857-B2 | Ion channel inhibitory compounds, pharmaceutical formulations, and uses | CACNA1I, CACNA1G, CACNA1H | CACNA1I 1/4885CACNA1H 3/4885CACNA1G 2/4885 |
| US-20180312471-A1 | Ion Channel Inhibitory Compounds, Pharmaceutical Formulations, and Uses | CACNA1I, CACNA1G, CACNA1H | CACNA1I 1/4885CACNA1H 3/4885CACNA1G 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.