Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18838565 | 0.90 | NR1H2 (0.33) | L3MBTL3L3MBTL1NR1H2NR1H3SLC6A2 | |
| SCHEMBL18838561 | 0.84 | NR1H2 (0.42) | GPR119NR1H2NR1H3 | |
| SCHEMBL18838576 | 0.80 | GPR119 (0.39) | GPR119L3MBTL3L3MBTL1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL18838569 | 0.79 | GPR119 (0.38) | GPR119L3MBTL3L3MBTL1NR1H2NR1H3 | |
| Hydrochloric Acid SCHEMBL18838568 | 0.79 | GPR119 (0.38) | GPR119L3MBTL3L3MBTL1NR1H2NR1H3 | |
| SCHEMBL18838597 | 0.77 | NR1H2 (0.37) | NR1H2NR1H3SLC6A2SLC6A4 | |
| SCHEMBL18838582 | 0.77 | NR1H2 (0.37) | NR1H2NR1H3SLC6A2SLC6A4 | |
| SCHEMBL18838570 | 0.72 | NR1H2 (0.41) | GPR119NR1H2NR1H3PGRNR3C2 | |
| SCHEMBL18838593 | 0.71 | GPR119 (0.42) | GPR119NR1H2NR1H3PGRNR3C2 | |
| SCHEMBL18921631 | 0.69 | GPR119 (0.37) | GPR119PGRNR3C2PLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3373933-A1 | BISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | Merck Sharp & Dohme Corp. (US) | 2018-09-19 | — | — | EP | disclosed |
| WO-2017083219-A1 | BISPIPERIDINYL DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE | MERCK SHARP & DOHME CORP. (US) | 2017-05-18 | — | — | WO | disclosed |