Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 19/20 | 0.83 |
| ▸ | ATR | Q13535 | 3/20 | 0.79 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.79 |
| ▸ | MTOR | P42345 | 15/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.70 |
| ▸ | PRKDC | P78527 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18824758 | 0.94 | ATM (0.77) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824768 | 0.92 | ATM (0.82) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL20550164 | 0.92 | ATM (0.91) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18844684 | 0.92 | ATM (0.91) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18844683 | 0.92 | ATM (0.91) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824545 | 0.91 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824912 | 0.91 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824921 | 0.90 | ATM (0.91) | ATMATRPIK3CAMTORKCNH2 | |
| SCHEMBL18844682 | 0.90 | ATM (0.91) | ATMATRPIK3CAMTORKCNH2 | |
| SCHEMBL18824925 | 0.90 | ATM (0.91) | ATMATRPIK3CAMTORKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |