Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 19/20 | 0.91 |
| ▸ | ATR | Q13535 | 3/20 | 0.91 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.75 |
| ▸ | MTOR | P42345 | 13/20 | 0.75 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.66 |
| ▸ | PRKDC | P78527 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18844684 | 1.00 | ATM (0.91) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL20550164 | 1.00 | ATM (0.91) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824831 | 0.95 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL20550138 | 0.95 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18844676 | 0.95 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824891 | 0.95 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824833 | 0.95 | ATM (1.00) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824631 | 0.93 | ATM (0.89) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18844649 | 0.93 | ATM (0.89) | ATMATRPIK3CAMTORPIK3CD | |
| SCHEMBL18824630 | 0.93 | ATM (0.89) | ATMATRPIK3CAMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180318287-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ASTRAZENECA AB (SE) | 2018-11-08 | — | — | US | disclosed |
| WO-2017076895-A1 | IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2017-05-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180318287-A1 | Imidazo[4,5-c]quinolin-2-one Compounds and Their Use in Treating Cancer | ATM, BRCA1, CHEK2 | ATM 1/4885ATR 10/4885PIK3CA 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.