Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17222716 | 0.74 | KDM4E (0.40) | KDM4EALDH1A1HPGDJAK2LMNA | |
| SCHEMBL15457139 | 0.70 | KDM4E (0.50) | KDM4ELMNAHTTMEN1KMT2A | |
| SCHEMBL22810868 | 0.68 | KMT2A (0.44) | KDM4EALDH1A1HPGDJAK2LMNA | |
| SCHEMBL31330832 | 0.68 | KDM4E (0.32) | KDM4EALDH1A1CYP1A2CYP2C9ALOX15 | |
| SCHEMBL18336468 | 0.67 | AADAT (0.41) | KDM4EALDH1A1HPGDLMNAMEN1 | |
| SCHEMBL15457156 | 0.66 | PDE10A (0.45) | KDM4EALDH1A1LMNADPP4DPP8 | |
| SCHEMBL25757694 | 0.64 | TSHR (0.35) | KDM4ELMNAMEN1KMT2ATSHR | |
| SCHEMBL24402003 | 0.63 | DPP4 (0.30) | DPP4DPP8 | |
| SCHEMBL18336487 | 0.63 | AADAT (0.39) | KDM4EALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL25359780 | 0.62 | ESR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079670-A9 | COMPOSITIONS COMPRISING AN INHIBITOR OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-06-15 | — | — | WO | disclosed |
| WO-2017079670-A1 | COMPOSITIONS COMPRISING AN INHIBITOR OF LYSINE SPECIFIC DEMETHYLASE-1 | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-05-11 | — | — | WO | disclosed |