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SCHEMBL1885144

SCHEMBL1885144

CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ncc4cc(-c5cnc([C@@]6(C(C)(C)C)CCCN6C(=O)O)n5COCC[Si](C)(C)C)ccc4n3)nc2)n1COCC[Si](C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ CHEK2 O96017 1/20 0.32
▸ GPR119 Q8TDV5 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1888628 0.92 DGAT1 (0.32) CHEK2GPR119
SCHEMBL1887124 0.91 CHEK2 (0.33) CHEK2GPR119
SCHEMBL1889464 0.90 CHEK2 (0.35) CHEK2GPR119
SCHEMBL1885141 0.90 CHEK2 (0.36) CHEK2GPR119
SCHEMBL1887085 0.87 CHEK2 (0.33) CHEK2GPR119
SCHEMBL1890115 0.87 CHEK2 (0.32) CHEK2GPR119
SCHEMBL1884892 0.85 CHEK2 (0.31) CHEK2GPR119
SCHEMBL934576 0.85 USP30 (0.33) CHEK2GPR119
SCHEMBL934276 0.83 CHEK2 (0.36) CHEK2GPR119
SCHEMBL12661134 0.83 CHEK2 (0.38) CHEK2GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110112100-A1 Hepatitis C Virus Inhibitors PFIZER INC. 2011-05-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110112100-A1 Hepatitis C Virus Inhibitors HAVCR2, SLC10A1, HCCS CHEK2 3724/4885GPR119 2249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.