Sugi Predict

Sugi Predict / Compounds / SCHEMBL1885175

SCHEMBL1885175

SCHEMBL1885175

CCOC(=O)n1nc(NC(=O)c2ccc(OC)cc2[N+](=O)[O-])c2c1CCN(S(=O)(=O)c1cc(F)cc(F)c1)C2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 2/20 0.38
▸ KMT2A Q03164 4/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ ALDH1A1 P00352 3/20 0.36
▸ MAPT P10636 4/20 0.35
▸ LMNA P02545 3/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ CYP3A4 P08684 4/20 0.35
▸ CYP2C19 P33261 3/20 0.35
▸ USP2 O75604 2/20 0.35
▸ TDP1 Q9NUW8 2/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ HTT P42858 2/20 0.35
▸ MCOLN3 Q8TDD5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2458396 0.90 MAPT (0.35) IGF1RKMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL1895529 0.90 ALDH1A1 (0.40) IGF1RKMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL2460044 0.90 IGF1R (0.38) IGF1RKMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL1883184 0.90 IGF1R (0.39) IGF1RKMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL2454995 0.89 IGF1R (0.40) IGF1RKMT2AL3MBTL1ALDH1A1MAPT
SCHEMBL1894731 0.88 IGF1R (0.50) IGF1RKMT2AMEN1L3MBTL1MAPT
SCHEMBL1890200 0.87 IGF1R (0.43) IGF1RKMT2AMEN1ALDH1A1MAPT
SCHEMBL1887029 0.87 IGF1R (0.36) IGF1RKMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL1888067 0.85 IGF1R (0.42) IGF1RKMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL1885047 0.84 IGF1R (0.39) IGF1RKMT2AMEN1L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8173659-B2 Substituted pyrazolo[4,3-C]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2012-05-08 — — US disclosed
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-09-22 — — US disclosed
US-7947686-B2 Substituted pyrazolo[4,3-c]pyridine derivatives active as kinase inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2011-05-24 — — US disclosed
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors NERVIANO MEDICAL SCIENCES S.R.L. (IT) 2009-01-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110230470-A1 SUBSTITUTED PYRAZOLO[4,3-C]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885KMT2A 1468/4885MEN1 3780/4885
US-20090023745-A1 Substituted Pyrazolo[4,3-c]Pyridine Derivatives Active as Kinase Inhibitors MAP3K3, MAP3K1, MAP3K19 IGF1R 760/4885KMT2A 1468/4885MEN1 3780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.