⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18088480 | 0.61 | MAPT (0.32) | — | |
| SCHEMBL18088454 | 0.61 | MAPT (0.32) | — | |
| SCHEMBL9246486 | 0.61 | MAPT (0.31) | — | |
| SCHEMBL10903034 | 0.58 | — | — | |
| SCHEMBL8475053 | 0.58 | — | — | |
| SCHEMBL15797939 | 0.56 | — | — | |
| SCHEMBL11023320 | 0.56 | — | — | |
| SCHEMBL6059054 | 0.55 | — | — | |
| SCHEMBL11707585 | 0.53 | MAPT (0.32) | — | |
| SCHEMBL22993938 | 0.51 | ALDH1A1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192109-B1 | BICYCLIC -AMINO ACID DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-7947738-B2 | Bicyclic γ-amino acid derivative | DAIICHI SANKYO COMPANY, LTD. (JP) | 2011-05-24 | — | — | US | disclosed |
| US-20100249229-A1 | BICYCLIC gamma-AMINO ACID DERIVATIVE | DAIICHI SANKYO COMPANY, LTD. (JP) | 2010-09-30 | — | — | US | disclosed |
| EP-2192109-A1 | BICYCLIC -AMINO ACID DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-06-02 | — | — | EP | disclosed |
| EP-0521571-B1 | Procedure for the preparation of bicyclo [3.2.0] hept-2-en-7-ones | ENICHEM SPA (IT) | 1995-09-13 | — | — | EP | disclosed |
| US-5191125-A | Procedure for the preparation of bicyclo [3.2.0]hept-2-en-7-ones | ENICHEM S.P.A. (IT) | 1993-03-02 | — | — | US | disclosed |
| EP-0521571-A2 | Procedure for the preparation of bicyclo [3.2.0] hept-2-en-7-ones | ENICHEM S.p.A. (IT) | 1993-01-07 | — | — | EP | disclosed |