Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.53 |
| ▸ | RORC | P51449 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.44 |
| ▸ | TACR1 | P25103 | 3/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4206100 | 1.00 | HTRA1 (0.53) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL4196684 | 1.00 | HTRA1 (0.53) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL15730092 | 1.00 | HTRA1 (0.53) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL15730122 | 1.00 | HTRA1 (0.53) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL24700140 | 0.88 | NAMPT (0.46) | HTRA1NR1H2NR1H3HCRTR2GPR119 | |
| SCHEMBL24700143 | 0.87 | HCRTR2 (0.47) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL205497 | 0.84 | HTRA1 (0.60) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL1782234 | 0.84 | HTRA1 (0.60) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL5201925 | 0.84 | HTRA1 (0.60) | HTRA1RORCMEN1KMT2ANR1H2 | |
| SCHEMBL9543379 | 0.84 | HTRA1 (0.60) | HTRA1RORCMEN1KMT2ANR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2017-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | HTRA1 2680/4885RORC 487/4885MEN1 2645/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.