SCHEMBL1885381

SCHEMBL1885381

CSc1nc(C)cc(C)n1

nearest known ligand 0.65

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.65
APOBEC3G Q9HC16 1/20 0.65
LMNA P02545 3/20 0.56
KMT2A Q03164 4/20 0.52
MEN1 O00255 3/20 0.52
HTT P42858 2/20 0.52
THRB P10828 1/20 0.52
ALDH1A1 P00352 3/20 0.50
GAA P10253 1/20 0.50
KDM4E B2RXH2 2/20 0.43
TSHR P16473 2/20 0.43
HSP90AB1 P08238 1/20 0.42
PKM P14618 1/20 0.42
HPGD P15428 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5766295 0.85 POLB (0.48) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL12871725 0.83 POLB (0.46) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL1598214 0.83 KMT2A (0.49) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL30718977 0.83 KMT2A (0.49) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL1902046 0.83 POLB (0.47) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL8018804 0.83 KMT2A (0.49) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL13020819 0.79 POLB (0.44) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL3461180 0.79 KMT2A (0.59) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL13064527 0.79 KMT2A (0.46) POLBAPOBEC3GLMNAKMT2AMEN1
SCHEMBL8429640 0.79 TSHR (0.65) POLBAPOBEC3GLMNAKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103739557-B A kind of synthetic method of 4,6-dimethyl-2-methanesulfonyl pyrimidine YELLOW RIVER DELTA JINGBO CHEMICAL RESEARCH INSTITUTE CO., LTD. (CN) 2015-10-21 CN claimed
CN-101514190-B Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis UNIV DONGHUA 2011-06-08 CN claimed
WO-2010091877-A2 PROCESS FOR PRODUCING AMBRISENTAN RATIOPHARM GMBH (DE) 2010-08-19 WO claimed
CN-101514190-A Method for preparing heterocyclic compounds of methyl mercapto under ionic liquid catalysis UNIV DONGHUA (CN) 2009-08-26 CN claimed
CN-101391984-A Method for carrying out methylation to pyrimidine heterocyclic compound containing sulfhydryl by dimethyl carbonate UNIV DONGHUA (CN) 2009-03-25 CN claimed
US-4547573-A BACTERICIDES ICI PHARMA (FR) 1985-10-15 US claimed
US-4504478-A Cephalosporin-1-oxide derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (FR) 1985-03-12 US claimed
US-4497949-A PHOTOTHERMOGRAPHY;COLOR FILMS;STORAGE STABILITY;ANTIFOGGING AGENTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-02-05 US claimed
US-4492692-A BACTERICIDE IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-01-08 US claimed
US-4463173-A ANTIBIOTIC, BACTERICIDE ICI PHARMA (FR) 1984-07-31 US claimed
EP-0113965-A2 Process for the preparation of cephalosporin derivatives ICI PHARMA (FR) 1984-07-25 EP claimed
EP-0031708-B1 CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES THEREFOR ICI PHARMA (FR) 1984-06-13 EP claimed
EP-0082648-A2 Cephalosporin derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-06-29 EP claimed
EP-0075434-A2 Cephalosporins, their preparation and their pharmaceutical compositions ICI PHARMA (FR) 1983-03-30 EP claimed
EP-0072608-A2 Process for the preparation of cephalosporin derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1983-02-23 EP claimed
CN-122039076-A Preparation method of 2-methyl sulfoxide pyrimidine derivative 石河子大学 2026-05-15 CN disclosed
CN-118501437-A Fluorescent lateral flow immunochromatography test strip for detecting CRP in blood plasma 西北师范大学 2024-08-16 CN disclosed
EP-0055562-A2 Cephalosporin derivatives ICI PHARMA (FR) 1982-07-07 EP disclosed
EP-0031708-A2 Cephalosporin derivatives, processes for their manufacture, pharmaceutical compositions containing them and intermediates therefor ICI PHARMA (FR) 1981-07-08 EP disclosed
US-4245033-A AN ORGANIC SILVER SALT, A HALIDE AND A SULFUR COMPOUND EXPOSED TO FORM A SILVER IMAGE OF HIGH CONTRAST AND STABILITY CANON KABUSHIKI KAISHA (JP) 1981-01-13 US disclosed