Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1882731 | 0.90 | ALDH1A1 (0.43) | KMT2AMEN1PTPN11RPS6KB1ALDH1A1 | |
| SCHEMBL1879254 | 0.90 | KMT2A (0.45) | KMT2AMEN1RPS6KB1ALDH1A1NPC1 | |
| SCHEMBL1891065 | 0.90 | HSD17B10 (0.53) | KMT2AMEN1ALDH1A1KDM4EPKM | |
| SCHEMBL4370293 | 0.89 | KMT2A (0.47) | KMT2AMEN1ALDH1A1KDM4EPKM | |
| SCHEMBL4370241 | 0.88 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1RAB9AKDM4E | |
| SCHEMBL1884480 | 0.88 | TSHR (0.46) | KMT2AMEN1RPS6KB1ALDH1A1NPC1 | |
| SCHEMBL4371258 | 0.88 | KMT2A (0.49) | KMT2AMEN1ALDH1A1KDM4EATM | |
| SCHEMBL4368494 | 0.86 | ALDH1A1 (0.44) | KMT2APTPN11ALDH1A1L3MBTL1GPR119 | |
| SCHEMBL4379844 | 0.84 | KMT2A (0.46) | KMT2AALDH1A1GPR119LMNAMAPT | |
| SCHEMBL1887570 | 0.84 | RPS6KB1 (0.45) | KMT2AMEN1RPS6KB1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939532-B2 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | claimed |
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | claimed |
| US-7939532-B2 | Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents | HOFFMANN-LA ROCHE INC. (US) | 2011-05-10 | — | — | US | disclosed |
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100292247-A1 | HETEROCYCLYL PYRIDYL SULFONAMIDE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | STS, TPMT, DPYD | KMT2A 3658/4885MEN1 918/4885PTPN11 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.