Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 19/20 | 0.46 |
| ▸ | JAK3 | P52333 | 15/20 | 0.46 |
| ▸ | JAK2 | O60674 | 10/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18855797 | 0.80 | JAK2 (0.49) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9991873 | 0.80 | JAK2 (0.49) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL9989736 | 0.78 | JAK2 (0.55) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105006 | 0.77 | JAK1 (0.61) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL2105652 | 0.77 | JAK2 (0.75) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL31120995 | 0.74 | JAK3 (0.66) | JAK1JAK3JAK2 | |
| SCHEMBL2104859 | 0.74 | JAK3 (0.66) | JAK1JAK3JAK2 | |
| SCHEMBL17122720 | 0.73 | JAK1 (0.69) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL17129858 | 0.73 | JAK1 (0.69) | JAK1JAK3JAK2TYK2 | |
| SCHEMBL18855803 | 0.73 | L3MBTL1 (0.35) | JAK1JAK3JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-B1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2017-05-17 | — | — | EP | disclosed |