Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.46 |
| ▸ | JAK2 | O60674 | 10/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 10/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.39 |
| ▸ | MST1R | Q04912 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18855883 | 0.79 | JAK1 (0.59) | JAK1JAK2JAK3 | |
| SCHEMBL18855969 | 0.70 | PRKCI (0.41) | JAK1JAK2JAK3AURKAFGFR1 | |
| SCHEMBL12555225 | 0.69 | JAK2 (0.48) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL4345280 | 0.67 | JAK2 (0.45) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL4357267 | 0.67 | JAK2 (0.45) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL9991873 | 0.66 | JAK2 (0.49) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL18855797 | 0.66 | JAK2 (0.49) | JAK1JAK2TYK2JAK3AURKA | |
| SCHEMBL18855410 | 0.66 | PRKCI (0.58) | JAK1JAK2AURKAFGFR1KDR | |
| SCHEMBL14697170 | 0.65 | JAK1 (0.55) | JAK1JAK2JAK3 | |
| SCHEMBL16477537 | 0.64 | JAK1 (0.60) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2506716-B1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2017-05-17 | — | — | EP | disclosed |