Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 16/20 | 0.59 |
| ▸ | JAK2 | O60674 | 7/20 | 0.59 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 8/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16477537 | 0.83 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL15203406 | 0.81 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL30173286 | 0.80 | JAK1 (0.59) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL28608390 | 0.80 | JAK1 (0.59) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL18855804 | 0.79 | JAK1 (0.46) | JAK1JAK2JAK3 | |
| SCHEMBL18855969 | 0.79 | PRKCI (0.41) | JAK1JAK2JAK3 | |
| SCHEMBL1934804 | 0.79 | JAK2 (0.60) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL1717444 | 0.79 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL2105053 | 0.79 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3 | |
| SCHEMBL10125409 | 0.79 | JAK1 (0.60) | JAK1JAK2HPGDSJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950692-A1 | NOVEL TRICYCLIC COMPOUNDS | AbbVie Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-2506716-B1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2017-05-17 | — | — | EP | disclosed |