Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 12/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.31 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18855597 | 1.00 | GPR119 (0.47) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| SCHEMBL18855854 | 0.81 | DPP4 (0.44) | TRPC3TRPC6KCNH2HRH3DGAT1 | |
| SCHEMBL24242875 | 0.76 | GPR119 (0.51) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| SCHEMBL30991254 | 0.76 | GPR119 (0.44) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| SCHEMBL21645375 | 0.76 | GPR119 (0.44) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| Hydrochloric Acid SCHEMBL30991239 | 0.75 | GPR119 (0.43) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| Hydrochloric Acid SCHEMBL21645371 | 0.75 | GPR119 (0.43) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| SCHEMBL31143103 | 0.72 | CHEK1 (0.40) | GPR119CHEK1PDE4D | |
| SCHEMBL31656637 | 0.72 | GPR119 (0.44) | GPR119TRPC3TRPC6CHEK1KCNH2 | |
| SCHEMBL18855856 | 0.71 | HRH3 (0.58) | GPR119HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950692-A1 | NOVEL TRICYCLIC COMPOUNDS | AbbVie Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-2506716-B1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2017-05-17 | — | — | EP | disclosed |