Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 13/20 | 0.45 |
| ▸ | CA1 | P00915 | 12/20 | 0.45 |
| ▸ | CA2 | P00918 | 12/20 | 0.45 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PLEC | Q15149 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.43 |
| ▸ | DNASE1L3 | Q13609 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18595016 | 0.88 | CA9 (0.59) | CA9CA1CA2CA12USP2 | |
| SCHEMBL16421785 | 0.78 | CA9 (0.61) | CA9CA1CA2CA12USP2 | |
| SCHEMBL15150500 | 0.77 | CA9 (0.59) | CA9CA1CA2CA12USP2 | |
| SCHEMBL15496806 | 0.76 | CA9 (0.55) | CA9CA1CA2CA12USP2 | |
| SCHEMBL12909292 | 0.75 | MEN1 (0.59) | CA9CA1CA2CA12USP2 | |
| SCHEMBL14526777 | 0.74 | CA9 (0.56) | CA9CA1CA2CA12USP2 | |
| SCHEMBL12909284 | 0.74 | USP2 (0.67) | CA9CA1CA2CA12USP2 | |
| SCHEMBL17067944 | 0.73 | CA9 (0.61) | CA9CA1CA2CA12USP2 | |
| SCHEMBL14527509 | 0.73 | CA9 (0.66) | CA9CA1CA2CA12USP2 | |
| SCHEMBL15145504 | 0.72 | CA9 (0.63) | CA9CA1CA2CA12USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650363-B2 | Integrin antagonist conjugates for targeted delivery to cells expressing LFA-1 | HOFFMANN-LA ROCHE INC. (US) | 2017-05-16 | — | — | US | disclosed |